Pratya Sirisilp, 19; Patiya Mulsarn, 25; Jenjira Seela, 19; and Ratcha Ratchanapakit, 23, were arrested in a raid on a Soi Potisan apartment. A total of about 60 methamphetamine tablets, a third of a gram of crystal meth and a loaded 22-caliber handgun were seized.
The 17 suspected drug dealers and users are detained at Pattaya Police Station.
Pattaya police chief Col. Nanthawut Suwanla-ong also said random checks at an unnamed entertainment area netted 13 people who returned positive drugs tests.
The crackdown against drug use began last month and will continue, he said.
The confiscated contraband included a pipe gun and several packets of amphetamines.